Further simplification of the general analysis of the intercalative drug-DNA interaction.
Indian J Biochem Biophys
;
1989 Apr; 26(2): 109-19
Article
Dans Anglais
| IMSEAR
| ID: sea-27951
ABSTRACT
The application of McGhee and von Hippel's general equation [J. Mol. Biol., 86 (1974), 469-489, Eq. (15)] to the analysis of the interaction of intercalative drugs with DNA has been further simplified. The value of n can now be determined mathematically, using a simple function, and without any approximation. It is also established that the summation of squared deviation of (( (nu/c), nu)) points would be minimum for and only for the true set of (K,n,omega) of the interaction system. The method incorporating the simplification has been applied to determine the binding parameters of adriamycin-DNA interaction according to the above general equation.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
ADN
/
Bovins
/
Interactions médicamenteuses
/
Intercalants
/
Animaux
/
Mathématiques
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1989
Type:
Article
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