Influence of 7beta-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: in vitro studies.
Indian J Biochem Biophys
;
2001 Jun; 38(3): 176-9
Article
Dans Anglais
| IMSEAR
| ID: sea-28189
ABSTRACT
Incubation of murine peritoneal macrophages with 7beta-hydroxycholesterol (7beta-OH) for 24 hr led to dose-dependent reduction in cellular glutathione content as well as nitrite levels in the medium. Treatment with an inorganic form of selenium, sodium selenite which is a potent antioxidant, elevated the cellular glutathione levels and decreased nitrite levels. Our results suggest that 7beta-OH may exert its pro-atherogenic effect by inhibiting glutathione synthesis and nitric oxide production by macrophages present in the arterial wall and thus, impair the cellular antioxidant defense system.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Artères
/
Sélénium
/
Facteurs temps
/
Cellules cultivées
/
Macrophages péritonéaux
/
Relation dose-effet des médicaments
/
Glutathion
/
Glutathione peroxidase
/
Hydroxycholestérols
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
2001
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS