Role of antibiotics in lipid peroxidation.
Indian J Biochem Biophys
;
1992 Aug; 29(4): 371-4
Article
Dans Anglais
| IMSEAR
| ID: sea-28672
ABSTRACT
Alterations in the levels of lipid peroxides, superoxide dismutase, catalase, glutathione, free fatty acid and serum ceruloplasmin were studied in rats fed with high fat cholesterol diet administered different antibiotics, viz. ampicillin, tetracycline, streptomycin, chloramphenicol and cephalosporin. The concentrations of lipid peroxides, glutathione, free fatty acid decreased in most of the tissues, except in tetracycline, streptomycin and cephalosporin treated rats. The changes observed in the activities of superoxide dismutase and catalase in the liver and kidney of these antibiotics administered groups also are in accordance with the changes in lipid peroxides. The results show that the tetracycline is hepatotoxic and nephrotoxic, while cephalosporin and streptomycin are nephrotoxic.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Superoxide dismutase
/
Mâle
/
Céruloplasmine
/
Cholestérol alimentaire
/
Distribution tissulaire
/
Peroxydation lipidique
/
Catalase
/
Rat Sprague-Dawley
/
Acides gras
langue:
Anglais
Texte intégral:
Indian J Biochem Biophys
Année:
1992
Type:
Article
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