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Glycoside-bearing liposomal delivery systems against macrophage-associated disorders involving Mycobacterium leprae and Mycobacterium tuberculosis.
Indian J Biochem Biophys ; 1995 Jun; 32(3): 147-51
Article Dans Anglais | IMSEAR | ID: sea-28833
ABSTRACT
Asiaticoside, a plant glycoside with rhamnose as end sugar and having microbicidal properties was tested against Mycobacterium leprae and Mycobacterium tuberculosis both in vivo and in vitro. As rhamnose is reported to have no tissue specificity, corchorusin D having glucose as end sugar was used for targeting with an equimolar proportion of asiaticoside in liposomal form for testing the drug value. Results showed that liposomal asiaticoside had better microbicidal property against M. leprae and M. tuberculosis when compared to that of free asiaticoside whereas liposomes containing asiaticoside and corchorusin D were found to be equally or more active in comparison to liposomal asiaticoside alone. It is inferred that appropriate glycosides, if used in liposomal form (incorporated or covalently grafted) have enhanced drug efficacy and such glycoside bearing liposomes as targeted delivery systems could be used for chemotherapeutic control of several other diseases.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Triterpènes / Tuberculose / Femelle / Mâle / Vecteurs de médicaments / Lèpre / Liposomes / Animaux / Macrophages / Souris langue: Anglais Texte intégral: Indian J Biochem Biophys Année: 1995 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Triterpènes / Tuberculose / Femelle / Mâle / Vecteurs de médicaments / Lèpre / Liposomes / Animaux / Macrophages / Souris langue: Anglais Texte intégral: Indian J Biochem Biophys Année: 1995 Type: Article