Serum surfactant protein-A levels in chronic bronchitis and its relation to smoking.
Indian J Chest Dis Allied Sci
;
2005 Jan-Mar; 47(1): 13-7
Article
Dans Anglais
| IMSEAR
| ID: sea-29704
ABSTRACT
BACKGROUND:
Surfactant protein-A (SP-A), which is an important constituent of natural surfactant, occurs physiologically in small amounts in blood. Tobacco smoke induces increased alveolo-capillary leakage of surfactant proteins into blood and its level in blood may help in the assessment of lung injury caused by smoke. Little is known on the SP-A levels in patients with chronic obstructive pulmonary disease (COPD).METHODS:
Prospective analytical study of 30 patients with clinical diagnosis of chronic bronchitis, which was made on the basis of symptoms, signs and chest radiographic findings. Serum SP-A and serum cotinine levels were measured.RESULTS:
Out of 30 patients, 21 were smokers and nine were non-smokers. The serum SP-A level in smokers with chronic bronchitis is significantly higher than the non-smokers. The plasma cotinine levels are also high in smokers. However, there was no correlation between the serum SP-A level and plasma cotinine level (r=0.044). Serum SP-A levels were related to age in smokers (r=0.566, p<0.01) but not in non-smokers with chronic bronchitis (r=0.017, p>0.05).CONCLUSION:
The increase in SP-A level in smokers with chronic bronchitis suggests that tobacco smoking causes a chronic increase in permeability of the lung parenchyma. The SP-A, a lung-specific secretory protein, is a potential marker for non-invasive assessment of the integrity of the lung epithelium. Further studies are required to find out whether SP-A can be used as a marker for early identification of smokers who are at risk of COPD.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Fumer
/
Études prospectives
/
Facteurs âges
/
Statistique non paramétrique
/
Cotinine
/
Bronchite chronique
/
Broncho-pneumopathie chronique obstructive
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Chest Dis Allied Sci
Année:
2005
Type:
Article
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