Genetic variants of beta-globin gene in Thai malaria patients.
Southeast Asian J Trop Med Public Health
;
2003 ; 34 Suppl 2(): 29-31
Article
Dans Anglais
| IMSEAR
| ID: sea-30636
ABSTRACT
Hemoglobin E (E26K variant of beta-globin gene) causing hemoglobinopathy is commonly observed in parts of Thailand, regardless of the hematologic disadvantage of the homozygotes. In order to detect further variants of the beta-globin gene, we performed variation screening for exon 1 of the beta-globin gene in 64 adult patients with P. falciparum malaria, living in northwest Thailand. We identified E26K and two novel variants, 59C>T and IVS+1G>T. IVS+1G>T lies on the splice donor site, and a substitution of A for G at the same site (IVS+1G>A) is known to be linked to beta-thalassemia. Thus, the biological significance of IVS+1G>T and its association with malarial infection should be clarified in future studies.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thaïlande
/
Variation génétique
/
Humains
/
Bêta-Globulines
/
Hémoglobine E
/
Réaction de polymérisation en chaîne
/
Paludisme à Plasmodium falciparum
/
Animaux
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
2003
Type:
Article
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