Three possible triggers to induce thrombocytopenia in dengue virus infection.
Southeast Asian J Trop Med Public Health
;
1987 Sep; 18(3): 351-5
Article
Dans Anglais
| IMSEAR
| ID: sea-31033
ABSTRACT
Changes in platelet count by dengue virus-platelet interaction and the participation of anti-DV antibody to such changes were studied in vitro with the aim to investigate a mechanism of how the DV causes prominent thrombocytopenia characteristically seen in DHF. The results obtained showed that (1) DV antigen attached to human platelets without immune-mediated reaction, (2) a decrease in platelet count was more markedly demonstrated by the binding of anti-DV antibody on the DV antigen associated with platelets than by the binding of the antigen-antibody complex on platelets, (3) a modulation of endothelial cell by the infection of DV to the cell was suggested as one of the causes of the thrombocytopenia.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thrombopénie
/
Plaquettes
/
Humains
/
Dengue
/
Virus de la dengue
/
Endothélium
/
Complexe antigène-anticorps
/
Réaction antigène-anticorps
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1987
Type:
Article
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