Heterogeneity of beta thalassaemia in Thailand.
Southeast Asian J Trop Med Public Health
;
1982 Dec; 13(4): 618-27
Article
Dans Anglais
| IMSEAR
| ID: sea-32227
ABSTRACT
Beta thalassaemia in Thailand is heterogeneous. Clinical, genetical, haematological and globin chain biosynthetic studies were performed in seven beta-thalassaemia families. The results showed different gene combinations. These were alpha-thalassaemia/homozygous beta 0-thalassaemia, questionable double heterozygosity between a beta-thalassaemia and a silent beta-thalassaemia genes with low Hb F of unexplained cause, silent beta-thalassaemia/beta+ - or beta 0-thalassaemia, high Hb A2 high Hb F-beta-thalassaemia - a new mutant, mild beta+-thalassaemia/Hb E, and beta 0-thalassaemia/heterocellular HPFH or delta beta-thalassaemia associated with alpha-thalassaemia. Most of variability of clinical and haematological findings in these families is due to heterogeneity of the beta-thalassaemia and related genes.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pedigree
/
Thalassémie
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Hémoglobine foetale
/
Hémoglobine A
/
Hémoglobine E
/
Enfant
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1982
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS