Levamisole and mebendazole in the treatment of bancroftian infection.
Southeast Asian J Trop Med Public Health
;
1978 Dec; 9(4): 571-5
Article
Dans Anglais
| IMSEAR
| ID: sea-32515
ABSTRACT
Levamisole and mebendazole, broad spectrum anthelminthic compounds were tested against microfilaria of Wuchereria bancrofti, and the results were compared with similarly treated diethylcarbamazine and untreated group. Levamisole at a dosage of 3 mg/kg daily for 8 days showed marked reduction in both microfilaria rate and microfilaria density and immediately thereafter mf-rate steadily increased almost up to pre-treatment level, the mf-density however showed only marginal increase. Mebendazole at dosage of 6 mg/kg daily for 10 days following 8 days treatment of levamisole also showed marginal increase of mf-rate but no increase of mf-density. Treatment with DEC at a dosage of 6 mg/kg daily for 12 days showed comparatively better results both in respect of reduction in mf-rate and mf-density. The reactions - severity and duration were more among levamisole treated groups as compared to DEC treated group. Thus with the dosages tried, DEC could be considered as a better drug than levamisole and mebendazole. Both the latter compounds had no or very limited effect on the adult worms of W. bancrofti.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Placebo
/
Wuchereria bancrofti
/
Benzimidazoles
/
Humains
/
Lévamisole
/
Diéthylcarbamazine
/
Filarioses
/
Mébendazole
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1978
Type:
Article
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