Risk of a couple having a child with severe thalassemia syndrome, prevalence in lower northern Thailand.
Southeast Asian J Trop Med Public Health
;
2006 Mar; 37(2): 366-9
Article
Dans Anglais
| IMSEAR
| ID: sea-32541
ABSTRACT
Thalassemia screening in pregnant women and their spouses was performed at Buddhachinaraj Provincial Hospital and 8 community hospitals in Phitsanulok; lower northern Thailand. The prevalence of thalassemic carrier state was determined of 1,198 couples. Of these, 4.8% had heterozygous alpha thalassemia-1, 1.6% had heterozygous beta thalassemia, 12.4% had heterozygous hemoglobin (Hb) E, 2.7% had homozygous Hb E and 0.25% of others had abnormal Hb. Eighteen at risk couples (1.5%) were identified. Fifteen couples were at risk for compound heterozygous Hb E / beta thalassemia and the remaining 3 were at risk for homozygous alpha thalassemia-1. Prenatal diagnosis (cordocentesis) was performed in 4 couples at risk, but no fetuses with severe thalassemic disease were detected.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Complications hématologiques de la grossesse
/
Diagnostic prénatal
/
Syndrome
/
Thaïlande
/
Thalassémie
/
Femelle
/
Humains
/
Mâle
/
Grossesse
/
État de porteur sain
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
2006
Type:
Article
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