Cost effectiveness in screening of class I HLA antibodies in Thai pregnant women.
Southeast Asian J Trop Med Public Health
;
1993 ; 24 Suppl 1(): 165-6
Article
Dans Anglais
| IMSEAR
| ID: sea-34015
ABSTRACT
Fifty-seven sera obtained from pregnant women who attended antenatal clinic were screened for class I HLA antibodies by standard microlymphocytotoxicity test. The age ranged from 20 to 40 years (mean +/- SD = 30.4 +/- 5). The lymphocytes obtained from 98 HLA-typed persons were used as the panel which would include all common HLA-A and HLA-B antigens and as many rare antigens as possible. Eight out of 57 sera (14%) had HLA antibodies which reacted as follows 3 sera had nonspecific antibodies, 3 sera had multispecific antibodies (B60 + B48 + B7, B60 + B61 + B13 and B51 + B35 + B53), one serum had a monospecific antibody (A2) and one serum was unidentified. The identified antibodies showed strong reactivity (r > 0.8). These sera will be used as HLA typing sera and exchanged with other HLA laboratories. The screening test for class I HLA antibodies in pregnant women attending the antenatal clinic is useful and practical. Several HLA antisera can be obtained at low cost. The cost of self-screening antisera was US$90/ml while the cost of commercial HLA typing sera is approximately US$250/ml, a factor to be considered by a new HLA laboratory with limited budget.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thaïlande
/
Femelle
/
Humains
/
Grossesse
/
Test d'histocompatibilité
/
Antigènes d'histocompatibilité de classe I
/
Dépistage de masse
/
Analyse coût-bénéfice
/
Adulte
/
Coûts et analyse des coûts
Type d'étude:
Etude diagnostique
/
Évaluation en économique de la santé
/
Étude pronostique
/
Étude de dépistage
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1993
Type:
Article
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