G6PD deficiency and fava bean consumption do not produce hemolysis in Thailand.
Southeast Asian J Trop Med Public Health
;
1991 Jun; 22(2): 176-82
Article
Dans Anglais
| IMSEAR
| ID: sea-34366
ABSTRACT
Favism, a hemolytic condition associated with fava bean consumption among the glucose-6-phosphate dehydrogenase (G6PD) deficient persons, is well described in the Middle East and Mediterranean areas. However, it is not well documented among the Thais or other Southeast Asians. It is possible that it does exist but that hemolysis which develops is of very minor degree and thus escapes clinical detection. This cross-sectional study hypothesizes that if the fava bean and G6PD deficiency interact in the Thai population, they should cause a significant difference in hematocrit level. The study was carried out in a community hospital in a malaria endemic area. We found that there was a trivial difference of the hematocrit (approximately 1%) which was too small to warrant any clinical significance after controlling for the extraneous effects of age, sex, use of malaria chemoprophylaxis, falciparum infection, use of analgesics/antipyretics and admission status of the patients (p = 0.668). This may be due to the presence of different G6PD mutants to those found elsewhere or due to different consumption patterns of fava beans among the Thais compared to people in other areas with high prevalence of G6PD deficiency.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Plantes médicinales
/
Thaïlande
/
Femelle
/
Humains
/
Mâle
/
Facteurs sexuels
/
Anti-inflammatoires non stéroïdiens
/
Études transversales
/
Enquêtes et questionnaires
/
Analyse de régression
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1991
Type:
Article
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