Maternal and viral factors in vertical transmission of HIV-1 subtype E.
Southeast Asian J Trop Med Public Health
;
1997 Dec; 28(4): 689-98
Article
Dans Anglais
| IMSEAR
| ID: sea-34753
ABSTRACT
Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 x 10(4) copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thaïlande
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
/
ARN viral
/
Données de séquences moléculaires
/
Infections à VIH
/
Réaction de polymérisation en chaîne
/
Adolescent
Type d'étude:
Étude pronostique
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1997
Type:
Article
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