Advantage of a two-dose versus one-dose varicella vaccine in healthy non-immune teenagers and young adults.
Southeast Asian J Trop Med Public Health
;
2004 Sep; 35(3): 697-701
Article
Dans Anglais
| IMSEAR
| ID: sea-35061
ABSTRACT
This study was undertaken to compare the immunogenicity and reactogenicity of two vaccines based on the attenuated Oka-strain of Varicella zoster virus (VZV), in adolescents and young adults. One hundred and eighty-six subjects, aged 13 to 29 years, were randomized to one of two groups to receive a one- or a two-dose VZV vaccine. Pre- and post-vaccination blood samples were assayed for VZV-specific IgG. Solicited local and general symptoms, as well as unsolicited symptoms, were recorded post-vaccination. Seroconversion rates were 94.9% in the one-dose, and 100% in the two-dose, regimen. The two-dose vaccine elicited significantly higher geometric mean antibody titer, 392.5 vs 86.8 pfu. Transient local injection site pain was the most frequently-reported symptom per dose in both groups (one dose 48.9%; two-dose 32.8%). The two-dose vaccine regimen afforded the advantage of higher antibody titers and potential increased protection from disease, without significantly increased reactogenicity.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thaïlande
/
Humains
/
Immunoglobuline G
/
Test ELISA
/
Études prospectives
/
Technique d'immunofluorescence
/
Adolescent
/
Calendrier vaccinal
/
Résultat thérapeutique
/
Herpèsvirus humain de type 3
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
2004
Type:
Article
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