The neurovirulence of flaviviruses in crab-eating monkeys (Macaca fascicularis).
Southeast Asian J Trop Med Public Health
;
1986 Dec; 17(4): 604-12
Article
Dans Anglais
| IMSEAR
| ID: sea-35566
ABSTRACT
The neurovirulent properties of attenuated dengue-2 and yellow fever (YF) vaccines, dengue-2 (DEN-2) and Japanese encephalitis (JE) viruses were studied in crab-eating monkeys (Macaca fascicularis). Number of central nervous system sites (as proportion affected) with neurovirulence (NV) lesions were compared. The results indicate that these monkeys reliably developed NV-lesion when inoculated with either JE or YF vaccine viruses (87%). NV-lesions occurred in a minority when inoculated with DEN-2 vaccine virus, were of minimal severity (9%), were probably biologically insignificant, and were of equal or less severity than lesions produced by its parental virus (10%).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Virulence
/
Virus de la fièvre jaune
/
Femelle
/
Mâle
/
Vaccins atténués
/
Vaccins antiviraux
/
Système nerveux central
/
Virus de la dengue
/
Virus de l'encéphalite japonaise (espèce)
/
Flavivirus
langue:
Anglais
Texte intégral:
Southeast Asian J Trop Med Public Health
Année:
1986
Type:
Article
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