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Isotypic antibody responses of a population in an endemic area of schistosomiasis japonica and their epidemiologic significance.
Southeast Asian J Trop Med Public Health ; 1997 Jun; 28(2): 268-73
Article Dans Anglais | IMSEAR | ID: sea-36005
ABSTRACT
The present study was designed to explore if there exists a correlation between predominant isotype-defined antibody levels and reinfection in low age groups of the population in an endemic area of schistosomiasis japonica in China. One hundred and thirty-eight individuals aged 3-25 years old were selected for serological investigations including the levels of IgG, IgG4, IgM and IgE, detected by ELISA with soluble egg antigen and soluble adult worm antigen. Results show that age is a determinant for SEA-specific IgG, IgG4, and IgE, and SWA-specific IgG and IgG4 antibody levels, which increased with age, and that SEA- and SWA- specific IgG4 antibody levels are risk factors of reinfection, ie, the risk of reinfection occurrence of the population with high level of SEA or SWA-specific IgG4 is 2.83 or 2.40 times, respectively, that with low level of SEA or SWA-specific IgG4, suggesting that in the endemic area of schistosomiasis japonica, there exists a possibility that in the population aged 3-25 years, SEA and SWA-specific IgG4 antibodies mediate a blocking immunity response.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Isotypes des immunoglobulines / Schistosomiase artérioveineuse / Femelle / Humains / Mâle / Test ELISA / Anticorps antihelminthe / Modèles logistiques / Odds ratio / Enfant Type d'étude: Etude d'étiologie / Étude de prévalence / Étude pronostique / Facteurs de risque Pays comme sujet: Asie langue: Anglais Texte intégral: Southeast Asian J Trop Med Public Health Année: 1997 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Isotypes des immunoglobulines / Schistosomiase artérioveineuse / Femelle / Humains / Mâle / Test ELISA / Anticorps antihelminthe / Modèles logistiques / Odds ratio / Enfant Type d'étude: Etude d'étiologie / Étude de prévalence / Étude pronostique / Facteurs de risque Pays comme sujet: Asie langue: Anglais Texte intégral: Southeast Asian J Trop Med Public Health Année: 1997 Type: Article