A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes.
Asian Pac J Allergy Immunol
;
1996 Dec; 14(2): 91-7
Article
Dans Anglais
| IMSEAR
| ID: sea-36496
ABSTRACT
In order to investigate whether there was any association between autoimmunity to pancreatic antigens with FCPD as well as IDDM, cell-mediated immune response to pancreatic antigens was studied by lymphoproliferation assay in 7 FCPD, 17 IDDM, 33 NIDDM patients and 102 normal controls. Optimal pancreatic antigen concentrations used were 100, 150 and 200 micrograms/ml. Positive results were considered for each concentration of antigens tested, at stimulation index (SI) > (mean +/- 2 SD) SI obtained from normal age-matched controls with the use of the corresponding concentration of antigen. The one who gave positive result with any of these optimal antigen concentrations was considered to be the responder to pancreatic antigens. With this criterion, the responders were found to be 3/7 (42.9%) FCPD, 6/17 (35.3%) IDDM and 6/33 (18.2%) NIDDM patients; while there were 11 of all 102 (10.8%) normal controls.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pancréas
/
Maladies du pancréas
/
Autoantigènes
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Calcinose
/
Lymphocytes
/
Adolescent
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
1996
Type:
Article
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