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Hepatocellular carcinoma: significance of HBV vertical transmission.
Asian Pac J Allergy Immunol ; 1998 Jun-Sep; 16(2-3): 93-103
Article Dans Anglais | IMSEAR | ID: sea-36582
ABSTRACT
In two cases of childhood hepatocellular carcinoma in Thailand, we established vertical transmission of hepatitis B virus infection as the underlying cause. With the first patient, the family history of HBV carriage became evident and a pedigree could be devised which demonstrated the high prevalence among the family members and hence evidence of vertical transmission. In the case of the second patient, we performed PCR and subsequent direct sequencing of HBV DNA isolated from his HBsAg-positive mother's, as well as from his serum, comparing the nucleotide sequences with those of a pregnant woman diagnosed as an asymptomatic HBV carrier, of another asymptomatic HBV carrier and of a reference strain, respectively, all belonging to the same genotype and subtype as the samples tested. Our results clearly indicate the necessity for nation-wide hepatitis B vaccination starting at birth, at least in hyperendemic areas like the Far East, in order to forestall HBV carriage and ensuing cirrhosis and/or HCC by preventing vertical transmission.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Pedigree / Thaïlande / Humains / Mâle / ADN viral / Données de séquences moléculaires / Séquence nucléotidique / Marqueurs biologiques / Enfant / Virus de l'hépatite B Type d'étude: Étude de prévalence Pays comme sujet: Asie langue: Anglais Texte intégral: Asian Pac J Allergy Immunol Année: 1999 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Pedigree / Thaïlande / Humains / Mâle / ADN viral / Données de séquences moléculaires / Séquence nucléotidique / Marqueurs biologiques / Enfant / Virus de l'hépatite B Type d'étude: Étude de prévalence Pays comme sujet: Asie langue: Anglais Texte intégral: Asian Pac J Allergy Immunol Année: 1999 Type: Article