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Reduced interleukin-17 expression of Burkholderia pseudomallei-infected peripheral blood mononuclear cells of diabetic patients.
Asian Pac J Allergy Immunol ; 2008 Mar; 26(1): 63-9
Article Dans Anglais | IMSEAR | ID: sea-36697
ABSTRACT
Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p < 0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.
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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Humains / ARN messager / Agranulocytes / Lymphocytes T / Burkholderia pseudomallei / Adulte / Interleukine-17 / Diabète de type 1 / Diabète de type 2 / Interleukine-23 Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Asian Pac J Allergy Immunol Année: 2008 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Humains / ARN messager / Agranulocytes / Lymphocytes T / Burkholderia pseudomallei / Adulte / Interleukine-17 / Diabète de type 1 / Diabète de type 2 / Interleukine-23 Type d'étude: Facteurs de risque langue: Anglais Texte intégral: Asian Pac J Allergy Immunol Année: 2008 Type: Article