Allogeneic bone marrow transplantation in an osteopetrosis patient: first report in Thailand.
Asian Pac J Allergy Immunol
;
1998 Dec; 16(4): 193-8
Article
Dans Anglais
| IMSEAR
| ID: sea-36758
ABSTRACT
We described the successful allogeneic matched sibling bone marrow transplantation (BMT) in a 5-year-old Thai boy in whom osteopetrosis was diagnosed on the basis of anemia, thrombocytopenia, leukoerythroblastosis, sclerotic bone, hepatosplenomegaly, and visual deficit from an encroachment of cranial nerve foramina. The preparative regimen included 4 days of busulfan 4 mg/kg/day, and 4 days of cyclophosphamide 50 mg/kg/day. Complete hematopoietic engraftment and no evidence of graft versus host disease were shown after BMT. Complete hematologic findings were corrected. His hematopoietic chimerism was changed to that of his donor. Post BMT, he has no hepatosplenomegaly. His bone radiographic findings revealed normal after BMT. Bone marrow biopsy showed normalized bone and bone marrow matrix. However, his vision remained impaired. We believe that this is the first case of successful bone marrow transplantation in an osteopetrosis patient in Thailand.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Ostéopétrose
/
Transplantation homologue
/
Humains
/
Mâle
/
Enfant d'âge préscolaire
/
Profilage d'ADN
/
Transplantation de moelle osseuse
/
Chimère obtenue par transplantation
/
Génotype
/
Maladie du greffon contre l'hôte
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
1998
Type:
Article
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