Discrimination between normal and malignant hepatocytes in man by the monoclonal antibody RL23/36: comparison with the Ca1 and 791T/36 monoclonal antibodies.
Asian Pac J Allergy Immunol
;
1989 Jun; 7(1): 51-5
Article
Dans Anglais
| IMSEAR
| ID: sea-36872
ABSTRACT
The monoclonal antibody RL23/36 has been shown to discriminate normal from malignant hepatocytes in man. In frozen sections of liver tissue from 25 Thai patients without hepatocellular carcinomas, the antibody reacted strongly and preferentially with hepatocytes. Reactivity with 7 hepatocellular carcinomas was invariably abnormal, being totally absent in 5 and partially lost in 2. This discrimination was superior to that achieved with Ca1 and 791T/36 monoclonal antibodies. In 2 cases of hepatocellular carcinoma, binding of RL23/36 to associated apparently non-malignant hepatocytes was abnormal, being absent in one and partially lost in the other. These data show that RL23/36 detects an antigenic determinant which is lost during malignant transformation of human hepatocytes, sometimes before the development of frank malignancy.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Coloration et marquage
/
Thaïlande
/
Biopsie
/
Humains
/
Différenciation cellulaire
/
Carcinome hépatocellulaire
/
Tumeurs du foie
/
Animaux
/
Anticorps monoclonaux
Type d'étude:
Étude pronostique
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
1989
Type:
Article
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