Neurotrophins: are they meaningful in chronic spontaneous urticaria?
Article
Dans Anglais
| IMSEAR
| ID: sea-36933
ABSTRACT
Plasma neurotrophin levels are elevated in patients with allergic and autoimmune diseases. The present study was designed to investigate the serum neurotrophin levels in 42 patients displaying chronic spontaneous urticaria, as well as 22 healthy control subjects. Blood samples were obtained from subjects during their first visit to the clinic, and then again after one month of desloratadine therapy. No significant difference was found between patient and control groups in terms of basal serum neurotrophin levels. However, basal nerve growth factor levels in patients whose symptoms persisted despite treatment were significantly lower than those of the drug-responsive patients and the control group. In treatment-responsive patients, nerve growth factor increased after suppression of the symptoms. Our study suggests that chronic spontaneous urticaria is linked with changes serum nerve growth factor levels, and that the deregulation of neurotrophins may contribute to urticaria pathophysiology.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Urticaire
/
Indice de gravité de la maladie
/
Femelle
/
Humains
/
Mâle
/
Résistance aux substances
/
Neuro-immunomodulation
/
Transduction du signal
/
Régulation de l'expression des gènes
/
Maladie chronique
langue:
Anglais
Année:
2008
Type:
Article
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