Seroprevalence of cytomegalovirus infection in children born to HIV-1 infected women.

ABSTRACT

Cytomegalovirus (CMV) is a frequent opportunistic infectious agent in children infected with human immunodeficiency virus type 1 (HIV-1). It has been implicated as a factor in the progression of HIV-1 disease. The aim of the present study was to evaluate the prevalence of CMV infection in Thai children born to HIV-1 infected women. The prevalence of CMV infection was 13, 89 and 84% in HIV-infected children and 9, 61 and 75% in HIV uninfected at age ranges of 0-12, 13-36 and 37-79 months, respectively. The prevalence of CMV infection was significantly different between HIV infected children (89%) and HIV uninfected (61%) at the age of 13-36 months (p < 0.05). The presence of CMV IgM in some children of age < 1 year suggested that CMV infection could occur early in life. Early co-infection may be important as they remain a risk factor for reactivation of latent CMV infection throughout the course of the HIV diseases. Clinical monitoring and appropriate work up may be of benefit in the early diagnosis and treatment of CMV disease.