Renin angiotensin aldosterone system and drug allergies complicated with hypotension.
Asian Pac J Allergy Immunol
;
2000 Jun; 18(2): 81-3
Article
Dans Anglais
| IMSEAR
| ID: sea-37020
ABSTRACT
It has been discussed in several studies that non-immunologic factors, such as renin angiotensin aldosterone system (RAAS) may play a role in the pathophysiology of anaphylaxis. This study aimed to determine whether RAAS plays a part in the fall in blood pressure during drug reactions or not. Twenty patients who experienced hypotension during drug reaction and 15 healthy volunteers were enrolled in this study. None of the patients in the study or control groups were under treatment with any drug that was capable of influencing to RAAS. Serum levels of angiotensin-I (A-I), angiotensin-II (A-II), angiotensin converting enzyme (ACE) and aldosterone were measured in both study and control groups. The Mann-Whitney U test was used to compare the results of the groups. There were no statistically significant differences between the groups with respect to A-I, A-II, ACE and aldosterone levels. It was concluded that a fall in blood pressure during drug reaction must be the result of mast cell mediator effects on the vascular wall rather than RAAS impairment.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Système rénine-angiotensine
/
Femelle
/
Humains
/
Mâle
/
Angiotensine-I
/
Angiotensine-II
/
Études de cohortes
/
Adolescent
/
Peptidyl-Dipeptidase A
/
Statistique non paramétrique
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
2000
Type:
Article
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