Preliminary clinical evaluation of a protein chip for tumor marker serodiagnosis of various cancers.
Asian Pac J Allergy Immunol
;
2003 Sep; 21(3): 171-8
Article
Dans Anglais
| IMSEAR
| ID: sea-37021
ABSTRACT
This preliminary study aimed to investigate sensitivity and specificity of a protein chip system for multi-tumor marker serodiagnosis of ten types of cancers, and to understand the possible clinical applications of this protein chip for the Thai population. The specific cancers diagnosed by this protein chip are lung, breast, liver, cervix, colo-rectal, stomach, ovary, esophagus, prostate and pancreas cancers. We analyzed 215 serum samples of which 165 were obtained from clinically confirmed cancer patients and 50 from healthy people with no evidence of cancer. The sensitivity and specificity of the protein chip were 82.4% and 94.0%, respectively. The success rate of the protein chip for detecting all 10 types of cancers varied from 57% to 100%. The value of the simultaneous measurement of multiple tumor markers using the protein chip for cancer screening lied in the higher sensitivity compared to using single tumor markers for each type of cancer. In short, protein chips may be useful in mass screening for cancer during health checkups as well as for metastasis follow-up of cancer patients.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Thaïlande
/
Sujet âgé de 80 ans ou plus
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Tests sérologiques
/
Antigènes glycanniques associés aux tumeurs
/
Alphafoetoprotéines
/
Antigène carcinoembryonnaire
Type d'étude:
Etude diagnostique
/
Études d'évaluation
/
Étude de dépistage
Limites du sujet:
Aged80
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
2003
Type:
Article
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