The effect of sodium crompromate in the prevention of exercise-induced asthma.

ABSTRACT

Sodium crompromate (SCP) is an isomer of disodium cromoglycate (DSCG). The two chemicals are pharmacologically similar but with different chemical synthesis. A comparative double-blind latin square study of the preventive effect of SCP and DSCG versus a placebo aerosol was carried out on a group of nine cases of exercise-induced asthma (EIA). Compared with the placebo, both SCP and DSCG were able to prevent asthma under exercise provocation, as monitored by chest auscultation and FEV1. There was no significant difference in the percentage fall of FEV1 on challenge. This suggests that SCP has a similar prophylactic effect as that of DSCG on EIA.