IN vitro cell-mediated immune reactions in herpes zoster patients treated with cimetidine.
Asian Pac J Allergy Immunol
;
1994 Jun; 12(1): 51-8
Article
Dans Anglais
| IMSEAR
| ID: sea-37179
ABSTRACT
In a double-blind placebo-control study the immunomodulating effect of cimetidine treatment for one week and placebo was investigated for cell-mediated immune reactions of 22 patients with herpes zoster (HZ). The mitogen induced leukocyte migration inhibition test (LMIT) and the in vitro proliferation of the patients' lymphocytes to exogenous IL-2 were used. Before any treatment, the mitogen induced leukocyte migration inhibition capacity (LMIC) of HZ patients was found to be significantly reduced (p < 0.02) as compared to healthy blood bank donors (controls). After one week, within the same treatment, the LMIC was significantly improved (p < 0.01). The patients' lymphoproliferative response to IL-2, before any treatment, was not significantly different from that of controls (p < 0.05). However, significantly higher values (p < 0.001) were found in patients tested 7 days after the disease onset as compared to those tested after 12 days. One-week cimetidine treatment significantly improved (p < 0.05) the lymphoproliferative response to IL-2 of initially low responders and had no effect on higher responder patients. In contrast to this, after one week of placebo treatment, a significant decrease in the patients' lymphoproliferative response to IL-2 could be observed as compared to patients' initial responses (p < 0.05) or to those of controls (p < 0.05). Although the number of cases is very small. The data suggest that after cimetidine treatment, as compared to placebo, healing from skin rash and pain was achieved in a significantly shorter time (p < 0.01).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sujet âgé de 80 ans ou plus
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Inhibition de la migration cellulaire
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Études cas-témoins
/
Méthode en double aveugle
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Interleukine-2
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Cimétidine
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
Limites du sujet:
Aged80
langue:
Anglais
Texte intégral:
Asian Pac J Allergy Immunol
Année:
1994
Type:
Article
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