Efficacy of cisplatin in early stage cervical cancer with a long waiting period for surgery.
Article
Dans Anglais
| IMSEAR
| ID: sea-37521
ABSTRACT
This study was undertaken as a prospective trial to evaluate the efficacy and safety of pre-operative cisplatin for controlling the tumor volume of stage IB-IIA cervical cancer patients whose schedule for radical surgery was longer than 3 weeks. Between June 2004 and July 2005, 42 patients were recruited to enter the study. Seventy-five mg/m(2) of cisplatin was administered for 1-2 courses. Cervical tumor volume was measured 1 day before chemotherapy and 1 day before the operation by using 3-dimensional ultrasound. Reduction of cervical tumor volume was noted in 76.2%of cases. The clinical stage, gross appearance of the tumor, histology and number of chemotherapy courses did not significantly affect chemo-responsiveness. The incidence of lymph node metastases was 16.3%. One patient experienced severe vomiting which could be controlled by ondansetron antiemetic. No severe hematologic or other non-hematologic toxicities were identified. In conclusion cisplatin is effective and safe for administration in a pre-operative setting for early stage cervical cancer patients whose surgical schedule is delayed more than 3 weeks.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Facteurs temps
/
Soins préopératoires
/
Femelle
/
Humains
/
Carcinome épidermoïde
/
Adénocarcinome
/
Tumeurs du col de l'utérus
/
Études prospectives
/
Cisplatine
/
Adulte
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Année:
2007
Type:
Article
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