Comparison of telomerase activity between malignant and tuberculous pleural effusions.
Article
Dans Anglais
| IMSEAR
| ID: sea-38457
ABSTRACT
OBJECTIVE:
To determine if telomerase activity can differentiate malignant from tuberculous pleural effusions.DESIGN:
Telomerase activity in malignant and tuberculous pleural effusions was measured in a blinded manner using a PCR-based telomeric repeat amplification protocol (TRAP) assay. MATERIAL ANDMETHOD:
Fifty-two patients with lymphocytic exudative pleural effusions were identified on thoracocentasis over a period of 18 months.RESULTS:
Telomerase activity was detected in 34% of malignant pleural fluid samples and 50% of tuberculous pleural effusions. The positive rate of telomerase activity was 30.7% for primary lung cancer and 37.5% for metastatic pleural effusion. The sensitivity and specificity of telomerase activity assay were extremely low (35.7% and 52.9%, respectively), compared with that of cytological examination (52.6% and 65.4%, respectively). Moreover the diagnostic accuracy of telomerase activity in combination with cytology was even lower than cytological examination alone (46.7% vs. 60%, respectively). This finding was in contrast to previous reports and demonstrated that the detection rate of telomerase activity in tuberculous pleural effusions was greater than that observed in malignant pleural exudates.CONCLUSION:
Telomerase activity does not appear to be a useful marker for differentiating malignant from tuberculous effusions.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Épanchement pleural
/
Tuberculose pleurale
/
Dosage biologique
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Marqueurs biologiques
/
Telomerase
/
Adulte
Type d'étude:
Guide de pratique
/
Étude pronostique
langue:
Anglais
Année:
2006
Type:
Article
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