Extrahepatic biliary atresia in twins: zygosity determination by short tandem repeat loci.
Article
Dans Anglais
| IMSEAR
| ID: sea-42686
ABSTRACT
Extrahepatic biliary atresia (EHBA) is an infantile obstructive cholangiopathy of unknown etiology. This condition is generally thought to be an acquired disease without familial tendency. We reported eight pairs of discordant twins in a series of 143 patients with operatively established EHBA, One pair was dizygotic twin from sex discrimination. Six were identical ABO blood groups and 2 were also the same minor blood groups (Dce, MM and Le a-b-). The last 2 sets were monzygotic twins by common DNA polymorphisms short tandem repeat loci. Our findings support the hypothesis that, EHBA is an acquired rather than a hereditary disease.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pedigree
/
Autoradiographie
/
Jumeaux
/
Atrésie des voies biliaires
/
Femelle
/
Humains
/
Mâle
/
Séquences répétées d'acides nucléiques
/
Réaction de polymérisation en chaîne
/
Études rétrospectives
Type d'étude:
Étude observationnelle
langue:
Anglais
Année:
1996
Type:
Article
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