An efficacy study of itraconazole in the treatment of Penicillium marneffei infection.
Article
Dans Anglais
| IMSEAR
| ID: sea-42922
ABSTRACT
OBJECTIVES:
to evaluate the efficacy and safety of itraconazole in treating P. marneffei infection.METHODS:
Ten patients with previously untreated P. marneffei infection were given oral itraconazole at a dose of 200 mg twice a day for 2 months, followed by a dose of 100 mg once a day for 1 month. Efficacy was determined by the clinical and microbiological cure.RESULTS:
All but one patient were seropositive for human immunodeficiency virus (HIV). Two patients died during therapy. Clinical improvement was evident in 8 patients. In 7 of these, the mean duration for becoming culture negative was 57 days. Five patients presented with relapse of P. marneffei infection within four months after completion of treatment.CONCLUSIONS:
Itraconazole was shown to be effective in the initial treatment of P. marneffei infection. Relapse after treatment is common and long-term suppressive therapy is recommended.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Penicillium
/
Femelle
/
Humains
/
Mâle
/
Adolescent
/
Séropositivité VIH
/
Itraconazole
/
Adulte
/
Kétoconazole
/
Adulte d'âge moyen
langue:
Anglais
Année:
1992
Type:
Article
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