The role of carbamylated hemoglobin in identifying acute and chronic renal failure.
Article
Dans Anglais
| IMSEAR
| ID: sea-43088
ABSTRACT
Carbamylated hemoglobin (CarbHb) levels expressed as valipe hydantoin (VH) were measured by high performance liquid chromatography (HPLC) in patients with acute renal failure (ARF, n=35) and chronic renal failure (CRF, n=39). CarbHb levels in CRF patients were approximately 2.5 times of those in ARF ones (121.2 +/- 8 vs 54.8 +/- 6 microgVH/gHb, p<0.01). CarbHb levels of 80 microgVH/gHb provided the best statistical values (sensitivity of 89% and specificity of 82%). CarbHb/BUN and Carb/Cr ratios were also effective determinants in differentiation between ARF and CRF. CarbHb/BUN ratio of 1.5 and CarbHb/Cr ratio of 20 were the best statistical cut off points. As such, measurement of CarbHb levels could be a reliable non-invasive method in identifying ARF from CRF patients.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Valine
/
Azote uréique sanguin
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Hémoglobine A
/
Études prospectives
/
Courbe ROC
/
Chromatographie en phase liquide à haute performance
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Année:
2002
Type:
Article
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