Comparison of topical prednisolone acetate, ketorolac tromethamine and fluorometholone acetate in reducing inflammation after phacoemulsification.
Article
Dans Anglais
| IMSEAR
| ID: sea-44651
ABSTRACT
AIMS:
To compare the efficacy and ocular adverse effects of topical prednisolone acetate, ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsification.METHOD:
One hundred and twenty eyes were enrolled in a prospective, investigator-masked, randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data were recorded weekly visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells and flare in the anterior chamber, and ocular symptoms.RESULTS:
The number of eyes with a minimal amount of cells in the anterior chamber in the ketorolac group was less than the prednisolone group on day 7 (1120, p = 0.008) and day 14 (2331, p = 0.015), and than fluorometholone group on day 7 (1121, p = 0.011). Intraocular pressure in the prednisolone group was higher than the ketorolac group on day 21 (14.612.2 mmHg, p = 0.016). One eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported frequently in the ketorolac group.CONCLUSION:
All 3 drugs were effective in reducing post-operative inflammation. The efficacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Complications postopératoires
/
Valeurs de référence
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Calendrier d'administration des médicaments
/
Fluorométholone
/
Prednisolone
/
Loi du khi-deux
Type d'étude:
Essai clinique contrôlé
/
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Année:
2003
Type:
Article
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