Assessment of antianginal efficacy of long-acting sustained release isosorbide dinitrate in comparison with short-acting isosorbide dinitrate.
Indian Heart J
;
1991 Mar-Apr; 43(2): 97-100
Article
Dans Anglais
| IMSEAR
| ID: sea-4620
ABSTRACT
A quadruple blind randomized cross-over study evaluated the therapeutic efficacy of twice a day long acting sustained release isosorbide dinitrate (SRISDN) in comparison with 4 times daily of the short acting isosorbide dinitrate in 18 patients with stable angina pectoris (NYHA class II-III) with a positive exercise treadmill test. The antianginal effect of sustained release isosorbide dinitrate (SRISDN) (exercise duration 472.61 +/- 112.49 sec and anginal episodes per week (1.33 +/- 1.18) was not significantly different (p less than 0.05) when compared to conventional isosorbide dinitrate (exercise duration 468.33 +/- 135.28 sec and anginal episodes per week 1.55 +/- 104). Twice a day long acting sustained release isosorbide dinitrate is as effective as four times a day conventional short acting isosorbide dinitrate. Such a regimen is likely to lead to a better patient compliance and ease of antianginal therapy.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Facteurs temps
/
Humains
/
Calendrier d'administration des médicaments
/
Adulte
/
Vaisseaux coronaires
/
Préparations à action retardée
/
Épreuve d'effort
/
Dinitrate isosorbide
/
Angine de poitrine
/
Adulte d'âge moyen
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Indian heart j
Année:
1991
Type:
Article
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