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Management of antitubercular drugs-induced hepatotoxicity and therapy reintroduction strategy in a TB clinic of Nepal.
Article Dans Anglais | IMSEAR | ID: sea-46529
ABSTRACT

BACKGROUND:

PZA, INH and R have potential for hepatotoxic side effects. Although anti-tuberculosis drug-induced hepatotoxicity is well known, there is no agreement on the clinical approach for cases in whom hepatotoxicity has developed.

OBJECTIVE:

To study the management of anti-TB drugs induced hepatotoxicity and the standard anti-TB drugs therapy reintroduction procedure.

DESIGN:

In prospective cohort analysis, 4 patients with active TB infection had developed anti-TB drugs induced hepatotoxicity. Retreatment of therapy was done on the basis of severity of hepatitis. If damage is mild, all the drugs were reintroduced at once in a tapering dose and if patient's condition is worse, INH and E is introduced in lower dose, later increasing the dose and the number of drugs.

Results:

All the patients tolerated anti-TB drugs well after reintroduction. There was no incidence of recurrence. All the patients completed their 8 months treatment regimen and all are cured.

CONCLUSION:

Timely detection and temporary withdrawal of the offending agent can completely cure anti-TB drugs induced hepatotoxicity. The recurrence of hepatotoxicity is rare if reintroduction in done in a well planned manner.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Tuberculose / Femelle / Humains / Mâle / Études prospectives / Adolescent / Adulte / Relation dose-effet des médicaments / Lésions hépatiques dues aux substances / Adulte d'âge moyen Type d'étude: Étude observationnelle Pays comme sujet: Asie langue: Anglais Année: 2005 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Tuberculose / Femelle / Humains / Mâle / Études prospectives / Adolescent / Adulte / Relation dose-effet des médicaments / Lésions hépatiques dues aux substances / Adulte d'âge moyen Type d'étude: Étude observationnelle Pays comme sujet: Asie langue: Anglais Année: 2005 Type: Article