Epstein-barr nuclear antigen-1 (EBNA-1) in diffuse large B-cell lymphoma and its relationship to the bcl-2 protein.
Acta Med Indones
;
2006 Apr-Jun; 38(2): 77-80
Article
Dans Anglais
| IMSEAR
| ID: sea-46999
ABSTRACT
AIM:
To determine EBNA-1 expression in the tissue of patients with diffuse large B-cell lymphoma and its relationship to bcl-2 expression.METHODS:
Paraffin-embedded tissue from 24 cases of diffuse large B-cell lymphoma were stained immunohisto chemically with monoclonal antibody anti-EBNA-1 and anti-bcl-2 using Streptavidin Biotin Complex method. The bcl-2 expression was measured as negative (no staining), positive 1 (weak staining), and positive 2 (moderate to strong staining). The relationship between the immunohisto chemistry results was examined.RESULTS:
From the 24 samples, 12 (50%) were EBNA-1 positive and 14 (58.3%) showed expression of bcl-2. Eleven of the 14 samples (90%) showed expression of bcl-2 were EBNA-1 positive, while only 3 of these samples (10%) were EBNA-1 negative. The relationship between bcl-2 expression and EBNA-1 was statistically significant (Chi square-uncorrected 11.2571, p= 0.0036).CONCLUSION:
Our results showed that 50% of diffuse large B-cell lymphoma were EBNA-1 positive. Furthermore, EBNA-1 seemed to be correlated with bcl-2 expression.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Immunohistochimie
/
Études transversales
/
Lymphome B
/
Lymphome B diffus à grandes cellules
/
Protéines proto-oncogènes c-bcl-2
/
Antigènes nucléaires du virus d'Epstein-Barr
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Acta Med Indones
Année:
2006
Type:
Article
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