The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro.
Acta Med Indones
;
2008 Apr; 40(2): 63-8
Article
Dans Anglais
| IMSEAR
| ID: sea-47139
ABSTRACT
AIM:
to examine the effect of A.paniculata on pancreatic b-cells.METHODS:
sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.001).RESULTS:
compared to the effect of 100 mM glibenclamide, 60 minutes incubation of BRIN-BD11 in KRB-3 containing 1.25 and 2.5 mg/mL A. paniculata evoked 1.5 fold (p=0.034) and 2.3 fold (p=0.001) insulin secretion. Twenty minutes incubation of BRIN-BD11 in KRB-3 + 0.625-5 mg/mL A.paniculata, evoked 1.4 - 4.7 fold (p = 0.002 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only. Twenty minutes incubation of BRIN-BD11 in KRB-1 containing 1.11 mM glucose + 0.625 - 10 mg/mL A.paniculata, evoked 1.3 - 3.7 fold (p = 0.019 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only.CONCLUSION:
this study conclude that A.paniculata was a very strong, dose dependent insulinotropic agent, glucose dependent and independent insulin secreting agent. This study also conclude that A.paniculata affected one of the membrane receptors, mostly ATP-dependent potassium channels (K+ATP).
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Glycémie
/
Humains
/
Extraits de plantes
/
Andrographis
/
Diabète de type 2
/
Cellules à insuline
/
Insuline
langue:
Anglais
Texte intégral:
Acta Med Indones
Année:
2008
Type:
Article
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