Cytogenetic effect of thioridazine hydrochloride in mice and in human lymphocyte chromosomes.
Ceylon Med J
;
1991 Sep; 36(3): 102-5
Article
Dans Anglais
| IMSEAR
| ID: sea-47894
ABSTRACT
Thioridazine hydrochloride, a drug of the phenothiazine group with a piperidine side chain is widely used in human medicine as a psycho-relaxant and anxiolytic agent. The mutagenic effects of thioridazine hydrochloride were studied in Swiss albino mice. The animals were treated with 4, 6 and 8 mg/kg of thioridazine hydrochloride for the micronucleus test, analysis of chromosomes in germ cells, and for sperm morphology assay. Human lymphocyte cultures were treated in vitro with 0.75, 1.25 and 1.75 mg/culture of thioridazine hydrochloride for 24, 48 and 72 hours. The study showed no significant increase in the frequency of micronuclei, chromosomal aberrations in germ cells and sperm head abnormalities in mice, or chromosomal aberrations in human lymphocyte cultures.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Spermatocytes
/
Thioridazine
/
Humains
/
Mâle
/
Lymphocytes
/
Tests de micronucleus
/
Aberrations des chromosomes
/
Animaux
/
Souris
langue:
Anglais
Texte intégral:
Ceylon Med J
Année:
1991
Type:
Article
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