Enteric fever caused by Salmonella isolates with decreased susceptibility to ciprofloxacin.
Ceylon Med J
;
2004 Dec; 49(4): 137-8
Article
Dans Anglais
| IMSEAR
| ID: sea-49109
ABSTRACT
With emerging drug resistance, ciprofloxacin became the frontline antibiotic against Salmonella strains causing enteric fevers worldwide. However, strains with decreased susceptibility to flouroquinolones have recently emerged as a problem in our region. Such strains are not detected by the routine disc diffusion method unless a nalidixic acid disc is also used. They are, however, important clinically since they show poor clinical responses and have higher faecal carriage rates following treatment with fluoroquinolones in usual doses. We report the first two cases of such strains in Sri Lanka, both acquired locally. We recommend the routine use of a nalidixic acid disc in sensitivity testing of Salmonella species, causing enteric fever in laboratories not determining minimum inhibitory concentrations (MICs) for fluoroquinolones in order to detect such strains, so that appropriate clinical decisions regarding antibiotic therapy can be made.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Salmonella paratyphi A
/
Salmonella typhi
/
Sri Lanka
/
Fièvre typhoïde
/
Humains
/
Ciprofloxacine
/
Tests de sensibilité microbienne
/
Études de suivi
/
Résultat thérapeutique
/
Appréciation des risques
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Ceylon Med J
Année:
2004
Type:
Article
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