Clinical utility of ketoconazole in cases of adrenocortical carcinoma.
Indian J Cancer
;
1991 Dec; 28(4): 196-201
Article
Dans Anglais
| IMSEAR
| ID: sea-50258
ABSTRACT
Ketoconazole, an imidazole derivative is known to decrease adrenal steroid biosynthesis by inhibiting cytochrome P450 dependent adrenal enzymes. Three patients of adrenal carcinoma treated with ketoconazole, 600-1200 mg daily showed significant fall in plasma and urinary cortisol levels, but no reduction in tumor size, one patient developed liver dysfunction which reverted back to normal on discontinuing the drug.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Enfant
/
Adolescent
/
Tumeurs corticosurrénaliennes
/
Adulte
/
Kétoconazole
langue:
Anglais
Texte intégral:
Indian J Cancer
Année:
1991
Type:
Article
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