Eosinophilic leukemoid reaction associated with carbamazepine hypersensitivity.
Indian J Dermatol Venereol Leprol
;
2005 Jan-Feb; 71(1): 35-7
Article
Dans Anglais
| IMSEAR
| ID: sea-52172
ABSTRACT
Carbamazepine is widely used in the treatment of epilepsy, neuralgic pain, and bipolar affective disorders. Several adverse drug reactions have been described during the course of carbamazepine administration, including exanthemata and hematological reactions. Carbamazepine is one of the common drugs that have been implicated in the etiology of drug hypersensitivity syndrome. A 50-year-old male presented with generalized erythroderma following 10 weeks of ingestion of carbamazepine 200 mg daily for idiopathic epilepsy. His systemic examination was within normal limits. Blood counts revealed marked eosinophilia of 52% (absolute eosinophil count of 10,400 per mm3). Bone marrow aspiration revealed a moderate increase in the eosinophilic series with cells showing normal morphology. The eosinophil counts returned to normal after 2 weeks of oral prednisolone therapy. This case is reported because of its rarity in the Indian medical literature.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Ponction-biopsie à l'aiguille
/
Humains
/
Mâle
/
Carbamazépine
/
Immunohistochimie
/
Études de suivi
/
Appréciation des risques
/
Maladies rares
/
Hypersensibilité médicamenteuse
/
Éosinophilie
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Dermatol Venereol Leprol
Année:
2005
Type:
Article
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