A study of oxidative stress in paucibacillary and multibacillary leprosy.
Indian J Dermatol Venereol Leprol
; 2008 Jan-Feb; 74(1): 80
Article
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| IMSEAR
| ID: sea-52860
BACKGROUND: The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment.Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. AIM: To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. METHODS: Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum.RESULTS: The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). CONCLUSION: There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Peau
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Superoxide dismutase
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Humains
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Peroxydation lipidique
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Enfant
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Enfant d'âge préscolaire
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Adolescent
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Stress oxydatif
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Adulte
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Lèpre
langue:
En
Texte intégral:
Indian J Dermatol Venereol Leprol
Année:
2008
Type:
Article