Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy.
Indian J Dermatol Venereol Leprol
;
2008 Jan-Feb; 74(1): 32-4
Article
Dans Anglais
| IMSEAR
| ID: sea-52980
ABSTRACT
BACKGROUND AND AIMS:
Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified.METHODS:
In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool.RESULTS:
According to this study, nine strong possible ligands can be identified.CONCLUSION:
These sites can be useful for further drug-development studies.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Liaison aux protéines
/
Virulence
/
Sites de fixation
/
Humains
/
Conception de médicament
/
Valeur prédictive des tests
/
Récepteur ErbB-2
/
Biologie informatique
/
Lèpre
/
Ligands
Type d'étude:
Etude d'étiologie
/
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Dermatol Venereol Leprol
Année:
2008
Type:
Article
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