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Safety and immunogenicity of the intradermal Thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine.
Indian J Med Microbiol ; 2005 Jan; 23(1): 24-8
Article Dans Anglais | IMSEAR | ID: sea-53838
ABSTRACT

PURPOSE:

To test the immunogenicity of the WHO recommended "2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatment centers throughout India.

METHODS:

Purified chick embryo cell vaccine (PCECV) was administered in the dosage of 0.1 mL per site to 53 Indian subjects.

RESULTS:

All subjects produced rabies antibodies above 0.5 IU/mL by day 14 post-vaccination. Only minor adverse reactions including swelling (6.6%), erythema (5.4%) and pain (1.4%) were observed for which no treatment was required.

CONCLUSIONS:

This study demonstrated that PCECV is safe and highly immunogenic in Indian subjects when administered intradermally as 0.1 mL/site using the "2-2-2-0-1-1" post-exposure regimen.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rage (maladie) / Croix-Rouge / Sécurité / Thaïlande / Humains / Immunoglobulines / Injections intradermiques / Vaccins antirabiques / Embryon de poulet / Calendrier vaccinal Pays comme sujet: Asie langue: Anglais Texte intégral: Indian J Med Microbiol Thème du journal: Microbiology Année: 2005 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rage (maladie) / Croix-Rouge / Sécurité / Thaïlande / Humains / Immunoglobulines / Injections intradermiques / Vaccins antirabiques / Embryon de poulet / Calendrier vaccinal Pays comme sujet: Asie langue: Anglais Texte intégral: Indian J Med Microbiol Thème du journal: Microbiology Année: 2005 Type: Article