Genotypic resistance profile of HIV-1 protease gene: a preliminary report from Vellore, south India.
Indian J Med Microbiol
;
2008 Apr-Jun; 26(2): 151-4
Article
Dans Anglais
| IMSEAR
| ID: sea-54138
ABSTRACT
HIV-1 subtypes other than B are responsible for most new HIV infections worldwide; virus sequence data for drug resistance is described only from a limited number of non-B subtype HIV-1. This study is on mutations and polymorphisms of HIV-1 protease gene that can predict drug resistance in subtype C. The genotypic resistance assay was carried out on 38 HIV-1 strains with their plasma RNA and in nine, the proviral protease gene was sequenced. The treatment naïve strains showed minor resistance mutations, there were no major resistance mutations in the protease gene. We suggest the use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
ARN viral
/
Protéase du VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Analyse de séquence d'ADN
/
Substitution d'acide aminé
/
Mutation faux-sens
/
Résistance virale aux médicaments
/
Génotype
/
Inde
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Med Microbiol
Thème du journal:
Microbiology
Année:
2008
Type:
Article
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