Cell proliferation and natural killer cell activity by polyherbal formulation, Immu-21 in mice.
Indian J Exp Biol
;
2002 Mar; 40(3): 282-7
Article
Dans Anglais
| IMSEAR
| ID: sea-55613
ABSTRACT
Immunomodulatory activity of an Ayurvedic polyherbal formulation, Immu-21 containing extracts of Ocimum sanctum, Withania somnifera, Emblica officinalis and Tinospora cordifolia was studied on proliferative response of splenic leukocytes to T cell mitogens, concanavalin (Con)-A and phytohemagglutinin (PHA) and B cell mitogen, lipopolysaccharide (LPS) in vitro by [3H]-thymidine uptake assay in mice. The cytotoxic activity of Immu-21 was tested by measuring the splenic leukocyte natural killer (NK) cell activity against K 562 cells. Intraperitoneal (i.p.) treatment with Immu-21 (30 mg/kg) once a day for 14 and 21 days did not cause change in body weight and spleen weight, where as splenocytes/spleen count was increased. Treatment of Immu-21 (30 mg/kg, i.p.) for 14 days and 1 mg/kg for 21 days significantly increased LPS induced leukocyte proliferation. NK cell activity was significantly increased when mice were pretreated with Immu-21 (10 and 30 mg/kg, i.p.) once a day for 7 days. The results indicate that pretreatment with Immu-21 selectively increased the proliferation of splenic leukocyte to B cell mitogen, LPS and cytotoxic activity against K 562 cells in mice.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Plantes médicinales
/
Humains
/
Extraits de plantes
/
Lymphocytes B
/
Cellules tueuses naturelles
/
Activation des lymphocytes
/
Lymphocytes T
/
Adjuvants immunologiques
/
Cellules K562
/
Cytotoxicité immunologique
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2002
Type:
Article
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