Hepatoprotective effect of a protein isolated from Cajanus indicus (Spreng) on carbon tetrachloride induced hepatotoxicity in mice.
Indian J Exp Biol
;
1998 Feb; 36(2): 175-81
Article
Dans Anglais
| IMSEAR
| ID: sea-55757
ABSTRACT
Treatment with hepatotoxin namely carbon tetrachloride (CCl4) (0.1 ml/100 g of body weight; twice a week) induced acute hepatic necrosis in Swiss albino mice (male; body weight 30 g +/- 2), with significant alteration in the activities of glutamic oxaloacetic transaminase (GOT); glutamic pyruvic transaminase (GPT); alkaline phosphatase (AP) and serum bilirubin. Administration of a protein fraction isolated from the leaves of C. indicus counteracted the action of CCl4 on transaminase, phosphatase showing hepatoprotection. Daily treatment with a purified protein fraction 'X' from the above plant (0.5 mouse ml i.p; 50-60 micrograms/ml) for a period of 7, 14, 21 days respectively showed decreased activities of serum transaminases alkaline phosphatase and decreased levels of serum bilirubin. These findings were further confirmed by histopathological study of liver.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Protéines végétales
/
Plantes médicinales
/
Mâle
/
Intoxication au tétrachlorure de carbone
/
Lésions hépatiques dues aux substances
/
Foie
/
Animaux
/
Souris
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1998
Type:
Article
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