Inhibition of rat brain nitric oxide synthase activity by cyclosporin-A.
Indian J Exp Biol
;
1996 Dec; 34(12): 1265-7
Article
Dans Anglais
| IMSEAR
| ID: sea-55780
ABSTRACT
Cyclosporin-A, a potent immunosuppressive agent is known to induce cellular toxic side effects by way of altering calcium homeostasis, including calcium/calmodulin mediated events. We studied the in vitro and in vivo effects of cyclosporin-A on rat brain nitric oxide synthase activity (the enzyme that mediates the conversion of L-arginine to citrulline and NO). CsA in concentrations of 22-4400 nM inhibited rat brain NOS activity in vitro and in 10 or 25 mg/kg wt/4 weeks of CsA treated rat brains in vivo. We report here that CsA by way of interfering with rat brain Ca2+/CaM mediated events may inhibit its NOS activity which ultimately may result in neurotoxicity.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Encéphale
/
Mâle
/
Ciclosporine
/
Rat Sprague-Dawley
/
Nitric oxide synthase
/
Antienzymes
/
Immunosuppresseurs
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1996
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS