Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) Loud. wood oil.
Indian J Exp Biol
;
1999 Mar; 37(3): 258-61
Article
Dans Anglais
| IMSEAR
| ID: sea-55997
ABSTRACT
Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lipoxygenase at a concentration of 200 micrograms/ml. Thus, the anti-inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Arbres
/
Huiles végétales
/
Mâle
/
Dégranulation cellulaire
/
Anti-inflammatoires non stéroïdiens
/
Inhibiteurs de la lipoxygénase
/
Rat Wistar
/
4-Méthoxyphénéthyl-méthyl-amine
/
Oedème
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1999
Type:
Article
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