Positive inotropic effect of Murraya koenigii (Linn.) Spreng extract on an isolated perfused frog heart.
Indian J Exp Biol
;
2006 Jun; 44(6): 481-4
Article
Dans Anglais
| IMSEAR
| ID: sea-56049
ABSTRACT
Ethanolic extract of fresh leaves of M. koenigii (MKEE) showed a dose dependent positive inotropic effect on isolated frog heart. The responses to MKEE (62.5-1000 microg) were not affected in either way by theophylline, imidazole, propranolol and sildenafil. The change in potassium and sodium concentration did not alter MKEE-induced positive inotropic effect. Lignocaine did not alter the responses to MKEE significantly. Responses to MKEE were significantly inhibited when calcium concentration was reduced to half (from 1.58 to 0.79 mM) and were significantly potentiated when calcium concentration was doubled (from 1.58 to 3.16 mM). Verapamil was found to inhibit the responses significantly. The results suggest that M. koenigii induced positive inotropic effect possibly by increasing availability of calcium from extra cellular sites.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Inhibiteurs de la phosphodiestérase
/
Pipérazines
/
Propranolol
/
Purines
/
Ranidae
/
Sulfones
/
Théophylline
/
Vasodilatateurs
/
Extraits de plantes
/
Vérapamil
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2006
Type:
Article
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